OpenAIのGPT-Rosalindは、Perry症候群に関連する遺伝子DCTN1の機能阻害がマウス脳データでコレステロール生成関連遺伝子の発現を高めることを示し、神経細胞にコレステロールが届いていない可能性という仮説を提示した。perturbai_txおよびScripps Researchとの共同研究では、数千のGPT-Rosalindエージェントが並列に動作し、数百万個のマウス脳細胞の遺伝子発現結果と科学文献を32分で照合した。OpenAIは今後この協業を拡大し、新たな創薬ターゲットの特定に取り組む。
GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration?
DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it.
That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders.
With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets.
https://openai.com/index/scaling-ai-research-for-complex-biological-data/
出典: OpenAI · x.com